2,2'-(p-Phenylenedioxy)diethanol

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  • Identifiers

    CAS number
    104-38-1

    Molecular formula
    C10H14O4

    SMILES
    C1=CC(=CC=C1OCCO)OCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 37.27%
    Balsamic 33.54%
    Floral 32.06%
    Sweet 30.24%
    Vanilla 28.55%
    Fresh 25.15%
    Rose 22.64%
    Alcoholic 22.23%
    Powdery 21.44%
    Animal 21.32%

     

    Flavor
    Sweet 62.05%
    Bitter 58.77%
    Creamy 38.54%
    Vanilla 37.95%
    Floral 34.94%
    Fruity 29.97%
    Mild 29.92%
    Musty 29.92%
    Balsam 29.77%
    Powdery 28.68%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.5

    pKa est.
    8.53 (weak base)

    Molecular weight
    198.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    437°C

    Flash point

    • 190.66 ˚C est.

  • Synonyms

    • 104-38-1
    • 1,4-Bis(2-hydroxyethoxy)benzene
    • Hydroquinone bis(2-hydroxyethyl) ether
    • Vernatzer 30/10
    • 2,2'-(p-Phenylenedioxy)diethanol
    • 2,2'-(Phenylenedioxy)diethanol
    • Hydroquinone diethylol ether
    • Hydroquinone di(2-hydroxyethyl) ether
    • 2,2'-p-Phenylenedioxydiethanol
    • NSC 1862
    • 1,4-(2-Hydroxyethoxy)benzene
    • Ethanol, 2,2'-(1,4-phenylenebis(oxy))bis-
    • Ethanol, 2,2'-(p-phenylenedioxy)di-
    • Bis(beta-hydroxyethyl) hydroquinone ether
    • 1,4-Bis(beta-hydroxyethoxy)benzene
    • EINECS 203-197-3
    • N2PVM9C37Q
    • 1,4-Bis(.beta.-hydroxyethoxy)benzene
    • Ethanol, 2,2'-[1,4-phenylenebis(oxy)]bis-
    • p-Phenylenebis(beta-hydroxyethyl) ether
    • Hydroquinone di(beta-hydroxyethyl) ether
    • Hydroquinone bis(beta-hydroxyethyl) ether
    • NSC-1862
    • p-di(2-hydroxyethoxy)benzene
    • hydroquinone dihydroxyethyl ether
    • EC 203-197-3
    • P-PHENYLENE BIS(.BETA.-HYDROXYETHYL ETHER)
    • RefChem:440178
    • Ethanol, 2,2'-(p-phenylenedioxy)di-(8CI)
    • P-PHENYLENE BIS(BETA-HYDROXYETHYL ETHER)
    • 203-197-3
    • Hydroquinone bis(2-hydroxyethyl)ether
    • 2,2'-(1,4-Phenylenebis(oxy))diethanol
    • 2-[4-(2-Hydroxyethoxy)phenoxy]ethanol
    • 1,4-Di(2-hydroxyethoxy)benzene
    • MFCD00002861
    • 2,2'-(1,4-Phenylenedioxy)diethanol
    • 2-[4-(2-hydroxyethoxy)phenoxy]ethan-1-ol
    • DTXSID5026702
    • 2,2'-[1,4-phenylenebis(oxy)]diethanol
    • p-Phenylenebis(.beta.-hydroxyethyl) ether
    • Hydroquinone di(.beta.-hydroxyethyl) ether
    • Bis(.beta.-hydroxyethyl) hydroquinone ether
    • Hydroquinone bis(.beta.-hydroxyethyl) ether
    • 41675-76-7
    • Ethanol,2'-(p-phenylenedioxy)di-
    • Ethanol,2'-[1,4-phenylenebis(oxy)]bis-
    • Hydroquinone, di(.beta.-hydroxyethyl) ether
    • UNII-N2PVM9C37Q
    • SCHEMBL48239
    • CBDivE_003503
    • DTXCID806702
    • SCHEMBL2152577
    • SCHEMBL3921149
    • CHEMBL3185174
    • NSC1862
    • HMS1578K16
    • 1,4-bis(2'-hydroxyethoxy)benzene
    • 1,4-Bis-(2-hydroxyethoxy)benzene
    • NSC26611
    • Tox21_200746
    • NSC-26611
    • AKOS015889507
    • FH40568
    • hydroquinone bis (2-hydroxyethyl) ether
    • NCGC00248819-01
    • NCGC00258300-01
    • BS-14346
    • CAS-104-38-1
    • 2-[4-(2-Hydroxyethoxy)phenoxy]ethanol #
    • 2-[4-(2-hydroxy-ethoxy)-phenoxy]-ethanol
    • CS-0076493
    • D1065
    • NS00006299
    • ST50405362
    • Hydroquinone bis(2-hydroxyethyl) ether, 98%
    • D70297
    • EN300-221305
    • 2,2'-[1,4-Phenylenebis(oxy)]di(ethan-1-ol)
    • F319939
    • Q27284430
    • F0001-0087
    • InChI=1/C10H14O4/c11-5-7-13-9-1-2-10(4-3-9)14-8-6-12/h1-4,11-12H,5-8H
    • 104-38-1

  • Applications

    Chemical name: 2,2'-(p-Phenylenedioxy)diethanol; CAS number: 104-38-1. This difunctional diol is used as a monomer/intermediate in polymer synthesis, particularly for polyurethane and polyester resins, where it acts as a diol component or crosslinker to enhance network formation and thermal performance. In coatings and inks, it serves as a crosslinking agent or reactive diluent in resin systems and UV-curable formulations. In adhesives, it is used as a chain extender or crosslinking component to improve mechanical strength and adhesion. In specialty polymers for electronics and optical materials, the aryl-ether diol can be a building block for rigid, high-Tg polymers and dielectric formulations. It may also be evaluated for other industrial polymer formulations, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 36.37
    methanol 74.81
    isopropanol 24.04
    water 2.72
    ethyl acetate 63.41
    n-propanol 23.65
    acetone 114.74
    n-butanol 17.9
    acetonitrile 83.26
    DMF 183.67
    toluene 9.23
    isobutanol 16.01
    1,4-dioxane 114.37
    methyl acetate 79.59
    THF 176.0
    2-butanone 57.4
    n-pentanol 20.8
    sec-butanol 19.91
    n-hexane 2.9
    ethylene glycol 47.68
    NMP 154.69
    cyclohexane 6.06
    DMSO 821.61
    n-butyl acetate 41.46
    n-octanol 15.1
    chloroform 80.62
    n-propyl acetate 43.93
    acetic acid 136.92
    dichloromethane 152.02
    cyclohexanone 79.95
    propylene glycol 30.65
    isopropyl acetate 31.25
    DMAc 244.46
    2-ethoxyethanol 97.95
    isopentanol 18.1
    n-heptane 5.83
    ethyl formate 50.51
    1,2-dichloroethane 104.14
    n-hexanol 18.41
    2-methoxyethanol 119.09
    isobutyl acetate 24.42
    tetrachloromethane 10.15
    n-pentyl acetate 20.49
    transcutol 205.14
    n-heptanol 11.6
    ethylbenzene 9.65
    MIBK 23.54
    2-propoxyethanol 59.23
    tert-butanol 51.8
    MTBE 37.38
    2-butoxyethanol 32.66
    propionic acid 51.74
    o-xylene 13.99
    formic acid 95.1
    diethyl ether 36.24
    m-xylene 9.79
    p-xylene 13.61
    chlorobenzene 22.1
    dimethyl carbonate 39.11
    n-octane 3.14
    formamide 162.02
    cyclopentanone 118.88
    2-pentanone 37.17
    anisole 32.59
    cyclopentyl methyl ether 50.4
    gamma-butyrolactone 178.74
    1-methoxy-2-propanol 63.67
    pyridine 59.71
    3-pentanone 39.45
    furfural 145.45
    n-dodecane 3.05
    diethylene glycol 81.79
    diisopropyl ether 12.25
    tert-amyl alcohol 35.1
    acetylacetone 79.04
    n-hexadecane 3.26
    acetophenone 42.12
    methyl propionate 54.67
    isopentyl acetate 33.44
    trichloroethylene 132.22
    n-nonanol 15.17
    cyclohexanol 26.47
    benzyl alcohol 29.27
    2-ethylhexanol 16.7
    isooctanol 10.98
    dipropyl ether 33.02
    1,2-dichlorobenzene 29.24
    ethyl lactate 36.53
    propylene carbonate 80.97
    n-methylformamide 86.35
    2-pentanol 13.44
    n-pentane 2.49
    1-propoxy-2-propanol 45.38
    1-methoxy-2-propyl acetate 46.53
    2-(2-methoxypropoxy) propanol 55.75
    mesitylene 9.11
    ε-caprolactone 75.27
    p-cymene 12.46
    epichlorohydrin 157.46
    1,1,1-trichloroethane 47.58
    2-aminoethanol 44.18
    morpholine-4-carbaldehyde 162.95
    sulfolane 276.13
    2,2,4-trimethylpentane 2.87
    2-methyltetrahydrofuran 81.51
    n-hexyl acetate 29.21
    isooctane 1.76
    2-(2-butoxyethoxy)ethanol 62.62
    sec-butyl acetate 25.71
    tert-butyl acetate 37.35
    decalin 4.61
    glycerin 72.91
    diglyme 145.88
    acrylic acid 59.56
    isopropyl myristate 16.34
    n-butyric acid 46.96
    acetyl acetate 61.46
    di(2-ethylhexyl) phthalate 18.23
    ethyl propionate 41.5
    nitromethane 280.76
    1,2-diethoxyethane 62.09
    benzonitrile 36.83
    trioctyl phosphate 14.23
    1-bromopropane 33.34
    gamma-valerolactone 138.08
    n-decanol 12.54
    triethyl phosphate 35.42
    4-methyl-2-pentanol 10.22
    propionitrile 44.78
    vinylene carbonate 71.87
    1,1,2-trichlorotrifluoroethane 138.69
    DMS 46.9
    cumene 9.06
    2-octanol 9.5
    2-hexanone 35.52
    octyl acetate 19.84
    limonene 17.81
    1,2-dimethoxyethane 160.03
    ethyl orthosilicate 32.07
    tributyl phosphate 21.09
    diacetone alcohol 46.64
    N,N-dimethylaniline 31.05
    acrylonitrile 66.34
    aniline 24.18
    1,3-propanediol 46.6
    bromobenzene 21.25
    dibromomethane 79.52
    1,1,2,2-tetrachloroethane 108.96
    2-methyl-cyclohexyl acetate 34.12
    tetrabutyl urea 30.67
    diisobutyl methanol 14.43
    2-phenylethanol 24.89
    styrene 12.23
    dioctyl adipate 32.99
    dimethyl sulfate 100.3
    ethyl butyrate 45.22
    methyl lactate 46.41
    butyl lactate 25.34
    diethyl carbonate 41.55
    propanediol butyl ether 35.19
    triethyl orthoformate 40.07
    p-tert-butyltoluene 11.72
    methyl 4-tert-butylbenzoate 39.22
    morpholine 113.87
    tert-butylamine 25.65
    n-dodecanol 11.02
    dimethoxymethane 96.92
    ethylene carbonate 64.12
    cyrene 64.08
    2-ethoxyethyl acetate 37.35
    2-ethylhexyl acetate 27.43
    1,2,4-trichlorobenzene 36.78
    4-methylpyridine 41.48
    dibutyl ether 26.54
    2,6-dimethyl-4-heptanol 14.43
    DEF 73.41
    dimethyl isosorbide 98.38
    tetrachloroethylene 59.57
    eugenol 38.89
    triacetin 55.61
    span 80 37.33
    1,4-butanediol 29.88
    1,1-dichloroethane 52.27
    2-methyl-1-pentanol 20.14
    methyl formate 83.98
    2-methyl-1-butanol 16.26
    n-decane 4.39
    butyronitrile 34.22
    3,7-dimethyl-1-octanol 16.68
    1-chlorooctane 12.42
    1-chlorotetradecane 6.94
    n-nonane 4.12
    undecane 3.54
    tert-butylcyclohexane 3.64
    cyclooctane 3.13
    cyclopentanol 35.93
    tetrahydropyran 64.69
    tert-amyl methyl ether 32.8
    2,5,8-trioxanonane 115.47
    1-hexene 8.38
    2-isopropoxyethanol 57.71
    2,2,2-trifluoroethanol 76.63
    methyl butyrate 54.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction