2-Methoxy-6-methylphenol

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  • Identifiers

    CAS number
    2896-67-5

    Molecular formula
    C8H10O2

    SMILES
    CC1=C(C(=CC=C1)OC)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 88.26%
    Sweet 81.59%
    Smoky 78.31%
    Spicy 72.91%
    Vanilla 72.32%
    Woody 65.68%
    Medicinal 63.85%
    Burnt 52.29%
    Clove 50.13%
    Balsamic 45.8%

     

    Flavor
    Phenolic 81.69%
    Sweet 72.31%
    Smoky 68.04%
    Vanilla 60.98%
    Bacon 58.96%
    Medicinal 58.83%
    Woody 58.51%
    Clove 56.16%
    Smoke 56.11%
    Spice 55.7%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    9.16 (weak base)

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    232°C

    Flash point

    • 86.21 ˚C est.

  • Synonyms

    • 2-Methoxy-6-methylphenol
    • 2896-67-5
    • Phenol, 2-methoxy-6-methyl-
    • 2-Hydroxy-3-methoxytoluene
    • UNII-BV9KQQ59VO
    • BV9KQQ59VO
    • NSC 7374
    • NSC-7374
    • DTXSID20183167
    • RefChem:87876
    • DTXCID30105658
    • 608-297-4
    • WBHAUHHMPXBZCQ-UHFFFAOYSA-N
    • MFCD00043771
    • 2-methoxy-6-methyl-phenol
    • 6-methoxy-2-methylphenol
    • 2-Hydroxy-3-methylanisole
    • o-Creosol
    • Guaiacol EP Impurity F
    • 2-hydroxy-3-methoxy-toluene
    • SCHEMBL50085
    • ghl.PD_Mitscher_leg0.672
    • orb3023559
    • SCHEMBL3890256
    • SCHEMBL4176958
    • SCHEMBL5362959
    • SCHEMBL11472626
    • SCHEMBL11472628
    • SCHEMBL29661990
    • NSC7374
    • SBB008271
    • AKOS006230634
    • PS-4138
    • BP-10123
    • SY101524
    • DB-015373
    • CS-0153682
    • NS00028588
    • ST50331330
    • EN300-202686
    • 896M675
    • F068334
    • Q27274909
    • 2896-67-5

  • Applications

    2-Methoxy-6-methylphenol (CAS 2896-67-5) is primarily used as an aroma-chemical in perfumery and cosmetics, acting as an odorant with characteristic notes and, in some formulations, as a fixative. It is also employed as an intermediate in the synthesis of fragrance-related compounds and other specialty chemicals. In polymer and coating systems, the compound may be evaluated as a stabilizer or antioxidant, potentially improving aging performance of formulations. In cleaning and household products, it can serve as a fragrance component to impart a distinctive scent, subject to regulatory and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1822.86
    methanol 1854.82
    isopropanol 1144.08
    water 24.59
    ethyl acetate 1328.13
    n-propanol 1402.85
    acetone 1797.28
    n-butanol 792.96
    acetonitrile 2194.2
    DMF 1357.49
    toluene 168.83
    isobutanol 750.0
    1,4-dioxane 3489.98
    methyl acetate 1524.28
    THF 2290.38
    2-butanone 1175.13
    n-pentanol 623.98
    sec-butanol 859.31
    n-hexane 88.05
    ethylene glycol 601.92
    NMP 636.13
    cyclohexane 116.02
    DMSO 2259.72
    n-butyl acetate 579.54
    n-octanol 299.54
    chloroform 1894.18
    n-propyl acetate 852.99
    acetic acid 1448.1
    dichloromethane 2136.36
    cyclohexanone 1023.27
    propylene glycol 452.91
    isopropyl acetate 547.86
    DMAc 482.26
    2-ethoxyethanol 1512.24
    isopentanol 540.93
    n-heptane 65.0
    ethyl formate 1128.4
    1,2-dichloroethane 1499.99
    n-hexanol 447.88
    2-methoxyethanol 1946.33
    isobutyl acetate 412.75
    tetrachloromethane 407.51
    n-pentyl acetate 358.27
    transcutol 1492.48
    n-heptanol 270.8
    ethylbenzene 164.25
    MIBK 440.75
    2-propoxyethanol 901.47
    tert-butanol 1332.47
    MTBE 998.98
    2-butoxyethanol 534.5
    propionic acid 1085.02
    o-xylene 143.21
    formic acid 846.51
    diethyl ether 1423.6
    m-xylene 149.44
    p-xylene 213.6
    chlorobenzene 370.39
    dimethyl carbonate 428.75
    n-octane 43.16
    formamide 1575.82
    cyclopentanone 1351.48
    2-pentanone 841.64
    anisole 518.48
    cyclopentyl methyl ether 724.84
    gamma-butyrolactone 1887.12
    1-methoxy-2-propanol 1048.36
    pyridine 839.33
    3-pentanone 580.02
    furfural 1176.66
    n-dodecane 33.78
    diethylene glycol 813.31
    diisopropyl ether 290.04
    tert-amyl alcohol 895.56
    acetylacetone 853.4
    n-hexadecane 38.34
    acetophenone 383.68
    methyl propionate 884.35
    isopentyl acetate 430.95
    trichloroethylene 2067.53
    n-nonanol 246.22
    cyclohexanol 497.47
    benzyl alcohol 368.58
    2-ethylhexanol 254.53
    isooctanol 225.09
    dipropyl ether 377.61
    1,2-dichlorobenzene 350.72
    ethyl lactate 310.9
    propylene carbonate 837.35
    n-methylformamide 1525.43
    2-pentanol 532.32
    n-pentane 87.51
    1-propoxy-2-propanol 538.11
    1-methoxy-2-propyl acetate 451.03
    2-(2-methoxypropoxy) propanol 346.0
    mesitylene 124.36
    ε-caprolactone 907.38
    p-cymene 104.15
    epichlorohydrin 2389.41
    1,1,1-trichloroethane 1208.38
    2-aminoethanol 904.69
    morpholine-4-carbaldehyde 1187.62
    sulfolane 1596.1
    2,2,4-trimethylpentane 56.86
    2-methyltetrahydrofuran 1439.42
    n-hexyl acetate 485.42
    isooctane 53.51
    2-(2-butoxyethoxy)ethanol 571.83
    sec-butyl acetate 404.45
    tert-butyl acetate 603.75
    decalin 63.61
    glycerin 567.55
    diglyme 1133.72
    acrylic acid 866.75
    isopropyl myristate 182.22
    n-butyric acid 1022.09
    acetyl acetate 557.33
    di(2-ethylhexyl) phthalate 127.21
    ethyl propionate 597.83
    nitromethane 3179.08
    1,2-diethoxyethane 696.28
    benzonitrile 418.73
    trioctyl phosphate 131.64
    1-bromopropane 666.72
    gamma-valerolactone 1693.75
    n-decanol 186.31
    triethyl phosphate 187.57
    4-methyl-2-pentanol 267.05
    propionitrile 1161.99
    vinylene carbonate 800.29
    1,1,2-trichlorotrifluoroethane 1027.17
    DMS 404.71
    cumene 133.63
    2-octanol 218.01
    2-hexanone 652.62
    octyl acetate 241.3
    limonene 142.94
    1,2-dimethoxyethane 1940.31
    ethyl orthosilicate 178.54
    tributyl phosphate 155.78
    diacetone alcohol 598.22
    N,N-dimethylaniline 262.98
    acrylonitrile 1389.47
    aniline 349.76
    1,3-propanediol 1183.42
    bromobenzene 347.92
    dibromomethane 1308.87
    1,1,2,2-tetrachloroethane 1370.21
    2-methyl-cyclohexyl acetate 263.0
    tetrabutyl urea 167.22
    diisobutyl methanol 171.05
    2-phenylethanol 313.73
    styrene 208.07
    dioctyl adipate 229.51
    dimethyl sulfate 554.83
    ethyl butyrate 421.97
    methyl lactate 367.17
    butyl lactate 240.84
    diethyl carbonate 292.25
    propanediol butyl ether 426.62
    triethyl orthoformate 265.09
    p-tert-butyltoluene 110.67
    methyl 4-tert-butylbenzoate 302.5
    morpholine 2719.35
    tert-butylamine 655.2
    n-dodecanol 139.61
    dimethoxymethane 1219.6
    ethylene carbonate 745.22
    cyrene 326.78
    2-ethoxyethyl acetate 506.27
    2-ethylhexyl acetate 318.54
    1,2,4-trichlorobenzene 400.86
    4-methylpyridine 594.96
    dibutyl ether 322.71
    2,6-dimethyl-4-heptanol 171.05
    DEF 665.77
    dimethyl isosorbide 564.2
    tetrachloroethylene 1027.82
    eugenol 319.52
    triacetin 375.16
    span 80 285.59
    1,4-butanediol 529.6
    1,1-dichloroethane 1315.91
    2-methyl-1-pentanol 411.66
    methyl formate 1365.55
    2-methyl-1-butanol 513.03
    n-decane 57.44
    butyronitrile 903.32
    3,7-dimethyl-1-octanol 224.21
    1-chlorooctane 202.07
    1-chlorotetradecane 79.99
    n-nonane 58.23
    undecane 43.09
    tert-butylcyclohexane 70.53
    cyclooctane 48.61
    cyclopentanol 718.03
    tetrahydropyran 1843.35
    tert-amyl methyl ether 537.75
    2,5,8-trioxanonane 635.87
    1-hexene 267.87
    2-isopropoxyethanol 837.79
    2,2,2-trifluoroethanol 611.98
    methyl butyrate 790.43

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction