2-Deoxyglucose

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  • Identifiers

    CAS number
    154-17-6

    Molecular formula
    C6H12O5

    SMILES
    C(C=O)[C@H]([C@@H]([C@@H](CO)O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 67.26%
    Sweet 32.99%
    Buttery 24.2%
    Caramellic 22.29%
    Savory 19.09%
    Milky 17.68%
    Alcoholic 16.28%
    Sharp 15.7%
    Bitter 15.5%
    Oily 15.37%

     

    Flavor
    Odorless 64.77%
    Sweet 36.05%
    Sweet-like 29.86%
    Very mild 25.23%
    Very slight 22.46%
    Mild 21.07%
    Bitter 20.65%
    Yeast 20.49%
    Acetoin 20.12%
    Bland 20.11%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.9

    pKa est.
    4.92 (weak acid)

    Molecular weight
    164.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 147°C (296.6°F)

    Boiling point

    • Decomposes

    Flash point

    • 202.99 ˚C est.

  • Synonyms

    • 2-deoxy-D-glucose
    • 154-17-6
    • Deoxyglucose
    • 2-Deoxy-D-arabino-hexose
    • (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
    • 2-Desoxy-D-glucose
    • 2-Deoxy-D-mannose
    • D-2-Deoxyglucose
    • 2 Deoxyglucose
    • D-arabino-2-desoxyhexose
    • 2 Deoxy D glucose
    • 2 Desoxy D glucose
    • D-Arabino-hexose, 2-deoxy-
    • 9G2MP84A8W
    • DTXSID1037648
    • BA-2758
    • NSC-15193
    • RefChem:471277
    • GlyTouCan:G23624QE
    • CHEBI:15866
    • CHEBI:23623
    • DTXCID001476484
    • G23624QE
    • 205-823-0
    • (4R,5S,6R)-6-(hydroxymethyl)oxane-2,4,5-triol
    • 2-Deoxyglucose
    • Ba 2758
    • D-arabino-2-Deoxyhexose
    • NSC 15193
    • 2-DG
    • MFCD00151328
    • 2-Deoxy-D-arabinohexose
    • HSDB 5484
    • D-Glucose, 2-deoxy-
    • Glucose, 2-deoxy-
    • arabino-Hexose, 2-deoxy-
    • UNII-9G2MP84A8W
    • 2-Desoxy-D-glucose [French]
    • CCRIS 9094
    • EINECS 205-823-0
    • D-2dGlc
    • BRN 1723331
    • 2-DEOXYLGLUCOSE
    • 2-Deoxy-D-arabino-hexose;D-Arabino-2-deoxyhexose
    • SCHEMBL7670
    • 4-01-00-04282 (Beilstein Handbook Reference)
    • CHEMBL2074932
    • 2-DEOXY-D-GLUCOSE [MI]
    • 2-DEOXY-D-GLUCOSE [HSDB]
    • MSK10862
    • 2-DEOXY-D-GLUCOSE [MART.]
    • 2-DEOXY-D-GLUCOSE [WHO-DD]
    • AKOS015919409
    • AKOS015924825
    • DB08831
    • EBC-463079
    • MD05187
    • 2-Deoxy-D-glucose, BioXtra, >=98%
    • AS-12502
    • SY031898
    • DB-024740
    • D0051
    • NS00099319
    • 54D176
    • D-arabino-Hexose, 2-deoxy- (6CI,8CI,9CI)
    • 2-Deoxy-D-glucose, >=98% (GC), crystalline
    • 2-Deoxy-D-glucose, >=99% (GC), crystalline
    • F024330
    • Q3266534
    • 5CFA0332-FB70-485D-A064-6C4C39E7CBA1
    • 154-17-6

  • Applications

    2-Deoxyglucose (CAS 154-17-6) is a glucose analogue widely used in biochemical and pharmaceutical research as a tool to probe cellular glucose uptake and glycolytic flux. It acts as a competitive substrate for glucose transporters and hexokinase, becoming 2-deoxyglucose-6-phosphate and inhibiting downstream glycolysis in cell culture, making it valuable for metabolic studies and screening of glycolysis inhibitors. It is employed in enzymology and metabolic flux analysis as a probe of hexokinase activity and pathway dynamics, and in in vitro tracer experiments to study how cells handle glucose. In cancer metabolism research, it is used to investigate dependence on glycolysis and to validate metabolic targets; in analytical settings it serves as a standard for carbohydrate metabolism assays. Availability and use are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 19.66
    methanol 127.79
    isopropanol 7.03
    water 2495.2
    ethyl acetate 1.96
    n-propanol 11.63
    acetone 6.93
    n-butanol 5.57
    acetonitrile 3.51
    DMF 399.71
    toluene 0.37
    isobutanol 5.15
    1,4-dioxane 10.44
    methyl acetate 2.26
    THF 10.43
    2-butanone 3.63
    n-pentanol 1.85
    sec-butanol 6.34
    n-hexane 0.12
    ethylene glycol 473.01
    NMP 313.83
    cyclohexane 0.81
    DMSO 1019.2
    n-butyl acetate 1.23
    n-octanol 1.47
    chloroform 0.29
    n-propyl acetate 1.03
    acetic acid 81.65
    dichloromethane 0.68
    cyclohexanone 8.62
    propylene glycol 143.35
    isopropyl acetate 1.37
    DMAc 168.17
    2-ethoxyethanol 34.11
    isopentanol 3.71
    n-heptane 0.62
    ethyl formate 4.78
    1,2-dichloroethane 1.14
    n-hexanol 2.87
    2-methoxyethanol 143.43
    isobutyl acetate 0.4
    tetrachloromethane 0.46
    n-pentyl acetate 0.86
    transcutol 30.73
    n-heptanol 2.0
    ethylbenzene 0.29
    MIBK 2.21
    2-propoxyethanol 17.97
    tert-butanol 10.1
    MTBE 1.7
    2-butoxyethanol 8.47
    propionic acid 25.93
    o-xylene 0.99
    formic acid 967.5
    diethyl ether 1.23
    m-xylene 0.71
    p-xylene 0.34
    chlorobenzene 0.24
    dimethyl carbonate 6.86
    n-octane 0.22
    formamide 671.02
    cyclopentanone 13.66
    2-pentanone 3.11
    anisole 1.15
    cyclopentyl methyl ether 5.26
    gamma-butyrolactone 22.32
    1-methoxy-2-propanol 50.94
    pyridine 2.88
    3-pentanone 2.9
    furfural 29.23
    n-dodecane 0.12
    diethylene glycol 78.58
    diisopropyl ether 0.6
    tert-amyl alcohol 8.67
    acetylacetone 7.5
    n-hexadecane 0.13
    acetophenone 2.55
    methyl propionate 5.14
    isopentyl acetate 1.08
    trichloroethylene 1.16
    n-nonanol 1.32
    cyclohexanol 8.41
    benzyl alcohol 3.07
    2-ethylhexanol 1.75
    isooctanol 1.65
    dipropyl ether 1.7
    1,2-dichlorobenzene 0.5
    ethyl lactate 6.26
    propylene carbonate 8.03
    n-methylformamide 171.9
    2-pentanol 2.95
    n-pentane 0.23
    1-propoxy-2-propanol 10.14
    1-methoxy-2-propyl acetate 4.5
    2-(2-methoxypropoxy) propanol 10.91
    mesitylene 0.85
    ε-caprolactone 9.85
    p-cymene 0.84
    epichlorohydrin 6.69
    1,1,1-trichloroethane 0.38
    2-aminoethanol 228.2
    morpholine-4-carbaldehyde 150.33
    sulfolane 148.95
    2,2,4-trimethylpentane 0.23
    2-methyltetrahydrofuran 4.95
    n-hexyl acetate 1.28
    isooctane 0.14
    2-(2-butoxyethoxy)ethanol 12.61
    sec-butyl acetate 0.67
    tert-butyl acetate 2.28
    decalin 0.24
    glycerin 442.48
    diglyme 25.26
    acrylic acid 47.57
    isopropyl myristate 0.59
    n-butyric acid 11.6
    acetyl acetate 2.11
    di(2-ethylhexyl) phthalate 1.63
    ethyl propionate 1.43
    nitromethane 63.73
    1,2-diethoxyethane 1.94
    benzonitrile 1.04
    trioctyl phosphate 1.41
    1-bromopropane 0.29
    gamma-valerolactone 37.26
    n-decanol 0.99
    triethyl phosphate 2.28
    4-methyl-2-pentanol 1.74
    propionitrile 1.88
    vinylene carbonate 7.06
    1,1,2-trichlorotrifluoroethane 46.35
    DMS 2.34
    cumene 0.36
    2-octanol 1.02
    2-hexanone 1.06
    octyl acetate 0.89
    limonene 1.45
    1,2-dimethoxyethane 17.95
    ethyl orthosilicate 1.88
    tributyl phosphate 1.35
    diacetone alcohol 14.09
    N,N-dimethylaniline 2.26
    acrylonitrile 4.43
    aniline 1.88
    1,3-propanediol 111.26
    bromobenzene 0.17
    dibromomethane 0.38
    1,1,2,2-tetrachloroethane 1.48
    2-methyl-cyclohexyl acetate 1.82
    tetrabutyl urea 2.94
    diisobutyl methanol 1.64
    2-phenylethanol 2.51
    styrene 0.24
    dioctyl adipate 1.47
    dimethyl sulfate 34.78
    ethyl butyrate 1.66
    methyl lactate 29.22
    butyl lactate 3.49
    diethyl carbonate 1.15
    propanediol butyl ether 13.53
    triethyl orthoformate 1.83
    p-tert-butyltoluene 0.95
    methyl 4-tert-butylbenzoate 5.29
    morpholine 21.47
    tert-butylamine 3.05
    n-dodecanol 0.79
    dimethoxymethane 31.51
    ethylene carbonate 4.94
    cyrene 31.34
    2-ethoxyethyl acetate 1.73
    2-ethylhexyl acetate 0.85
    1,2,4-trichlorobenzene 0.71
    4-methylpyridine 1.88
    dibutyl ether 0.66
    2,6-dimethyl-4-heptanol 1.64
    DEF 22.1
    dimethyl isosorbide 16.77
    tetrachloroethylene 2.09
    eugenol 7.03
    triacetin 3.53
    span 80 9.5
    1,4-butanediol 32.97
    1,1-dichloroethane 0.28
    2-methyl-1-pentanol 1.61
    methyl formate 60.32
    2-methyl-1-butanol 4.45
    n-decane 0.2
    butyronitrile 1.23
    3,7-dimethyl-1-octanol 1.39
    1-chlorooctane 0.38
    1-chlorotetradecane 0.19
    n-nonane 0.22
    undecane 0.15
    tert-butylcyclohexane 0.16
    cyclooctane 0.5
    cyclopentanol 12.37
    tetrahydropyran 3.22
    tert-amyl methyl ether 2.35
    2,5,8-trioxanonane 21.43
    1-hexene 0.18
    2-isopropoxyethanol 10.53
    2,2,2-trifluoroethanol 79.96
    methyl butyrate 2.32

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction