2-Chloropropane

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  • Identifiers

    CAS number
    75-29-6

    Molecular formula
    C3H7Cl

    SMILES
    CC(C)Cl

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Ethereal 60.93%
    Solvent 48.24%
    Fermented 47.07%
    Alcoholic 39.3%
    Pungent 38.38%
    Gassy 38.08%
    Fresh 35.64%
    Sweet 35.21%
    Camphoreous 34.31%
    Musty 32.82%

     

    Flavor
    Fishy 43.65%
    Meaty 32.71%
    Ammoniacal 32.58%
    Sulfurous 30.28%
    Onion 28.34%
    Ammonia 25.91%
    Glue 22.95%
    Bloody 21.94%
    Gassy 21.4%
    Sulfury 21.19%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    8.69 (weak base)

    Molecular weight
    78.54 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -178.9 °F (NTP, 1992)
    • -117.2 °C

    Boiling point

    • 96.33 °F at 760 mmHg (NTP, 1992)
    • 35.7 °C

    Flash point

    • -35.58 ˚C est.
    • -26 °F (NTP, 1992)
    • -32 °C
    • -26 °F (-32 °C) (CLOSED CUP)

    Solubility expt.

    • Miscible with alcohol, ether
    • SOL IN BENZENE
    • SOL IN METHANOL
    • In water = 3,050 mg/l at 25 °C

  • Synonyms

    • 2-CHLOROPROPANE
    • 75-29-6
    • Isopropyl chloride
    • Propane, 2-chloro-
    • Isopropylchloride
    • 2-Propyl chloride
    • Isoprid
    • Narcosop
    • sec-Propyl chloride
    • Chlorodimethylmethane
    • 2-CHLORO-PROPANE
    • CCRIS 874
    • HSDB 5204
    • UNII-VU39J8AJ2N
    • EINECS 200-858-8
    • UN2356
    • BRN 1730782
    • iso-C3H7Cl
    • AI3-18025
    • CHLOROPROPANE, 2-
    • VU39J8AJ2N
    • 2-CHLOROPROPANE [HSDB]
    • ISOPROPYL CHLORIDE [MI]
    • DTXSID6047739
    • EC 200-858-8
    • 4-01-00-00191 (Beilstein Handbook Reference)
    • UN 2356
    • 2-CHLOROPROPANE (1,1,1,2,3,3,3-D7)
    • monochloropropane
    • 2Propyl chloride
    • secPropyl chloride
    • Propane, 2chloro
    • iso-propyl chloride
    • MFCD00000867
    • 2-Chloropropane, 99%
    • 2-Chloropropane, >=99%
    • DTXCID0027723
    • R 280DA
    • 2-Chloropropane, analytical standard
    • STL480907
    • AKOS009156966
    • DB-021181
    • NS00003474
    • EN300-139045
    • 2-Chloropropane [UN2356] [Flammable liquid]
    • Q209360
    • F0001-1898

  • Applications

    2-Chloropropane, CAS 75-29-6, is primarily used as an alkylating reagent and synthetic intermediate in organic synthesis. It serves as a building block for isopropyl-containing derivatives, such as isopropylamines and other isopropylated compounds, via nucleophilic substitution and related transformations. In industrial settings, it is treated as a precursor for fine chemicals across pharmaceuticals, agrochemicals, polymers and plastics, and coatings/inks sectors. Depending on process and local regulations, it may also be encountered as a reactive intermediate in certain manufacturing steps.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 256.49
    methanol 261.02
    isopropanol 227.6
    water 10.44
    ethyl acetate 208.99
    n-propanol 237.35
    acetone 299.45
    n-butanol 244.99
    acetonitrile 178.14
    DMF 293.84
    toluene 156.8
    isobutanol 195.15
    1,4-dioxane 359.96
    methyl acetate 217.09
    THF 524.64
    2-butanone 289.3
    n-pentanol 154.73
    sec-butanol 248.58
    n-hexane 166.59
    ethylene glycol 113.83
    NMP 438.52
    cyclohexane 223.73
    DMSO 222.64
    n-butyl acetate 287.11
    n-octanol 237.03
    chloroform 575.61
    n-propyl acetate 152.64
    acetic acid 305.86
    dichloromethane 344.84
    cyclohexanone 392.81
    propylene glycol 180.99
    isopropyl acetate 161.84
    DMAc 337.31
    2-ethoxyethanol 183.08
    isopentanol 189.77
    n-heptane 256.59
    ethyl formate 121.49
    1,2-dichloroethane 208.52
    n-hexanol 361.95
    2-methoxyethanol 279.41
    isobutyl acetate 122.03
    tetrachloromethane 211.05
    n-pentyl acetate 186.94
    transcutol 512.28
    n-heptanol 209.52
    ethylbenzene 94.91
    MIBK 153.51
    2-propoxyethanol 368.28
    tert-butanol 300.41
    MTBE 283.5
    2-butoxyethanol 256.76
    propionic acid 247.73
    o-xylene 139.6
    formic acid 96.0
    diethyl ether 258.19
    m-xylene 127.86
    p-xylene 132.41
    chlorobenzene 178.05
    dimethyl carbonate 96.5
    n-octane 85.2
    formamide 89.77
    cyclopentanone 430.81
    2-pentanone 240.65
    anisole 160.55
    cyclopentyl methyl ether 357.57
    gamma-butyrolactone 360.78
    1-methoxy-2-propanol 262.6
    pyridine 258.31
    3-pentanone 233.65
    furfural 294.63
    n-dodecane 61.81
    diethylene glycol 233.34
    diisopropyl ether 126.58
    tert-amyl alcohol 298.99
    acetylacetone 213.55
    n-hexadecane 65.34
    acetophenone 160.1
    methyl propionate 188.51
    isopentyl acetate 234.15
    trichloroethylene 395.66
    n-nonanol 210.45
    cyclohexanol 325.22
    benzyl alcohol 130.88
    2-ethylhexanol 268.22
    isooctanol 157.3
    dipropyl ether 335.74
    1,2-dichlorobenzene 175.37
    ethyl lactate 117.93
    propylene carbonate 233.0
    n-methylformamide 142.05
    2-pentanol 210.14
    n-pentane 155.72
    1-propoxy-2-propanol 385.25
    1-methoxy-2-propyl acetate 248.67
    2-(2-methoxypropoxy) propanol 250.18
    mesitylene 96.5
    ε-caprolactone 317.27
    p-cymene 136.47
    epichlorohydrin 305.53
    1,1,1-trichloroethane 360.97
    2-aminoethanol 180.08
    morpholine-4-carbaldehyde 346.63
    sulfolane 390.85
    2,2,4-trimethylpentane 82.25
    2-methyltetrahydrofuran 437.05
    n-hexyl acetate 277.38
    isooctane 55.87
    2-(2-butoxyethoxy)ethanol 302.06
    sec-butyl acetate 126.94
    tert-butyl acetate 200.13
    decalin 88.79
    glycerin 199.71
    diglyme 442.55
    acrylic acid 216.0
    isopropyl myristate 154.92
    n-butyric acid 266.03
    acetyl acetate 163.2
    di(2-ethylhexyl) phthalate 128.65
    ethyl propionate 148.34
    nitromethane 261.28
    1,2-diethoxyethane 246.73
    benzonitrile 157.22
    trioctyl phosphate 110.99
    1-bromopropane 220.69
    gamma-valerolactone 385.67
    n-decanol 162.9
    triethyl phosphate 118.57
    4-methyl-2-pentanol 127.28
    propionitrile 175.36
    vinylene carbonate 191.21
    1,1,2-trichlorotrifluoroethane 320.5
    DMS 166.43
    cumene 80.15
    2-octanol 158.88
    2-hexanone 189.19
    octyl acetate 200.04
    limonene 240.1
    1,2-dimethoxyethane 258.96
    ethyl orthosilicate 124.57
    tributyl phosphate 125.9
    diacetone alcohol 236.96
    N,N-dimethylaniline 136.09
    acrylonitrile 173.55
    aniline 192.9
    1,3-propanediol 183.51
    bromobenzene 169.88
    dibromomethane 305.06
    1,1,2,2-tetrachloroethane 372.29
    2-methyl-cyclohexyl acetate 204.43
    tetrabutyl urea 162.65
    diisobutyl methanol 158.32
    2-phenylethanol 196.54
    styrene 108.29
    dioctyl adipate 186.69
    dimethyl sulfate 127.36
    ethyl butyrate 218.78
    methyl lactate 143.65
    butyl lactate 175.76
    diethyl carbonate 142.47
    propanediol butyl ether 262.25
    triethyl orthoformate 180.56
    p-tert-butyltoluene 145.63
    methyl 4-tert-butylbenzoate 225.78
    morpholine 381.07
    tert-butylamine 248.07
    n-dodecanol 138.01
    dimethoxymethane 190.11
    ethylene carbonate 169.77
    cyrene 192.62
    2-ethoxyethyl acetate 188.62
    2-ethylhexyl acetate 216.08
    1,2,4-trichlorobenzene 220.45
    4-methylpyridine 245.5
    dibutyl ether 255.32
    2,6-dimethyl-4-heptanol 158.32
    DEF 247.84
    dimethyl isosorbide 339.05
    tetrachloroethylene 278.97
    eugenol 195.56
    triacetin 252.72
    span 80 311.8
    1,4-butanediol 99.12
    1,1-dichloroethane 304.4
    2-methyl-1-pentanol 141.49
    methyl formate 110.08
    2-methyl-1-butanol 208.37
    n-decane 96.79
    butyronitrile 174.2
    3,7-dimethyl-1-octanol 210.86
    1-chlorooctane 171.58
    1-chlorotetradecane 91.83
    n-nonane 103.83
    undecane 73.5
    tert-butylcyclohexane 87.36
    cyclooctane 111.86
    cyclopentanol 319.47
    tetrahydropyran 418.66
    tert-amyl methyl ether 267.51
    2,5,8-trioxanonane 331.47
    1-hexene 212.29
    2-isopropoxyethanol 168.12
    2,2,2-trifluoroethanol 142.65
    methyl butyrate 171.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction