1-Piperidinepropanoic acid

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  • Identifiers

    CAS number
    26371-07-3

    Molecular formula
    C8H15NO2

    SMILES
    C1CCN(CC1)CCC(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 57.84%
    Fishy 38.3%
    Cheesy 30.02%
    Animal 29.52%
    Savory 25.51%
    Meaty 25.03%
    Nutty 23.55%
    Roasted 21.93%
    Popcorn 21.57%
    Cooked 18.94%

     

    Flavor
    Odorless 47.07%
    Mild 30.62%
    Bitter 26.33%
    Fatty 26.03%
    Faint 22.98%
    Sweet-like 22.3%
    Animal 22.22%
    Yeast 22.04%
    Alkaline 21.35%
    Bay oil 21.03%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.7

    pKa est.
    7.88 (neutral)

    Molecular weight
    157.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    265°C

    Flash point

    • 132.84 ˚C est.

  • Synonyms

    • 26371-07-3
    • 1-Piperidinepropionic acid
    • 1-Piperidinepropanoic acid
    • 3-piperidin-1-ylpropanoic acid
    • PIPERIDINEPROPIONIC ACID
    • 3-piperidinopropanoic acid
    • 3-(1-Piperidinyl)propanoic acid
    • 3-(1-Piperidinyl)propionic acid
    • 3-piperidinopropionic acid
    • UNII-6L69A7VPHO
    • 3-piperidin-1-ylpropionic acid
    • EINECS 247-633-0
    • DTXSID1067201
    • Propanoic acid, 3-(1-piperidyl)-
    • RefChem:77033
    • DTXCID5037494
    • PIPERIDINEPROPIONIC ACID [INCI]
    • 247-633-0
    • InChI=1/C8H15NO2/c10-8(11)4-7-9-5-2-1-3-6-9/h1-7H2,(H,10,11
    • LPDGWMLCUHULJF-UHFFFAOYSA-N
    • 3-(piperidin-1-yl)propanoic acid
    • MFCD00006515
    • Piperidine-1-propionic acid
    • 3-(1-piperidyl)propanoic acid
    • 6L69A7VPHO
    • 3-Piperidin-1-yl-propionic acid
    • 1-piperidine propionic acid
    • beta-piperidinopropionic acid
    • Oprea1_832578
    • SCHEMBL94068
    • SCHEMBL1243285
    • SCHEMBL1377167
    • SCHEMBL6261266
    • 3-(piperidin-1-yl)propanoicacid
    • 1-Piperidinepropionic acid, 96%
    • 3-(1-piperidinyl)-propanoic acid
    • 3-piperidin-1-ium-1-ylpropanoate
    • ALBB-000112
    • BB_SC-06616
    • STR04941
    • BBL001402
    • STK501193
    • AKOS002160520
    • CS-W016221
    • NCGC00335487-01
    • FP112125
    • SY082576
    • DB-046941
    • NS00028093
    • ST50759166
    • AB01005454-01
    • AB01005454-03
    • AF-936/31256033
    • F223466
    • SR-01000596886
    • SR-01000596886-1
    • Q27265091
    • 26371-07-3

  • Applications

    1-Piperidinepropanoic acid (CAS 26371-07-3) is primarily used as a versatile building block in pharmaceutical and fine-chemical synthesis, enabling access to piperidine-containing drug candidates and heterocyclic scaffolds through amide, ester, and related transformations. It is commonly employed as an intermediate for amino acid-like scaffolds and peptidomimetics, supporting SAR exploration. The compound also serves as a precursor in the synthesis of agrochemicals featuring a piperidine motif and can act as a starting material for ligands in catalytic and coordination chemistry research. Overall, it functions as a general-purpose amine/acid synthon for the controlled elaboration of drug-like molecules, subject to applicable regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.53
    methanol 62.36
    isopropanol 3.35
    water 44.97
    ethyl acetate 4.92
    n-propanol 8.84
    acetone 4.46
    n-butanol 6.46
    acetonitrile 2.05
    DMF 17.01
    toluene 2.93
    isobutanol 6.86
    1,4-dioxane 4.31
    methyl acetate 3.37
    THF 19.12
    2-butanone 3.76
    n-pentanol 5.04
    sec-butanol 3.74
    n-hexane 0.51
    ethylene glycol 54.91
    NMP 148.25
    cyclohexane 0.65
    DMSO 93.72
    n-butyl acetate 15.76
    n-octanol 3.79
    chloroform 9.76
    n-propyl acetate 5.77
    acetic acid 101.32
    dichloromethane 9.29
    cyclohexanone 28.57
    propylene glycol 39.43
    isopropyl acetate 5.75
    DMAc 35.76
    2-ethoxyethanol 22.43
    isopentanol 9.07
    n-heptane 0.7
    ethyl formate 13.11
    1,2-dichloroethane 7.36
    n-hexanol 12.09
    2-methoxyethanol 48.89
    isobutyl acetate 5.04
    tetrachloromethane 6.58
    n-pentyl acetate 7.23
    transcutol 122.14
    n-heptanol 6.54
    ethylbenzene 2.42
    MIBK 6.89
    2-propoxyethanol 38.17
    tert-butanol 9.27
    MTBE 2.2
    2-butoxyethanol 22.62
    propionic acid 50.32
    o-xylene 5.4
    formic acid 206.61
    diethyl ether 0.84
    m-xylene 5.71
    p-xylene 3.47
    chlorobenzene 6.02
    dimethyl carbonate 7.14
    n-octane 0.21
    formamide 141.97
    cyclopentanone 46.61
    2-pentanone 4.46
    anisole 4.95
    cyclopentyl methyl ether 11.45
    gamma-butyrolactone 96.06
    1-methoxy-2-propanol 24.1
    pyridine 9.41
    3-pentanone 4.04
    furfural 106.09
    n-dodecane 0.17
    diethylene glycol 67.72
    diisopropyl ether 1.17
    tert-amyl alcohol 10.72
    acetylacetone 16.59
    n-hexadecane 0.2
    acetophenone 13.18
    methyl propionate 6.38
    isopentyl acetate 18.35
    trichloroethylene 23.21
    n-nonanol 3.6
    cyclohexanol 11.65
    benzyl alcohol 12.48
    2-ethylhexanol 8.68
    isooctanol 5.95
    dipropyl ether 3.27
    1,2-dichlorobenzene 11.94
    ethyl lactate 15.79
    propylene carbonate 65.06
    n-methylformamide 35.95
    2-pentanol 2.97
    n-pentane 0.27
    1-propoxy-2-propanol 26.47
    1-methoxy-2-propyl acetate 26.25
    2-(2-methoxypropoxy) propanol 34.54
    mesitylene 4.84
    ε-caprolactone 41.48
    p-cymene 5.28
    epichlorohydrin 37.61
    1,1,1-trichloroethane 8.42
    2-aminoethanol 68.64
    morpholine-4-carbaldehyde 66.49
    sulfolane 239.48
    2,2,4-trimethylpentane 0.65
    2-methyltetrahydrofuran 12.9
    n-hexyl acetate 9.74
    isooctane 0.48
    2-(2-butoxyethoxy)ethanol 41.77
    sec-butyl acetate 4.9
    tert-butyl acetate 11.46
    decalin 0.98
    glycerin 112.52
    diglyme 58.26
    acrylic acid 71.15
    isopropyl myristate 3.64
    n-butyric acid 47.01
    acetyl acetate 11.91
    di(2-ethylhexyl) phthalate 12.41
    ethyl propionate 5.97
    nitromethane 52.67
    1,2-diethoxyethane 6.42
    benzonitrile 10.44
    trioctyl phosphate 7.52
    1-bromopropane 1.87
    gamma-valerolactone 76.98
    n-decanol 2.57
    triethyl phosphate 13.73
    4-methyl-2-pentanol 4.66
    propionitrile 3.18
    vinylene carbonate 48.83
    1,1,2-trichlorotrifluoroethane 112.24
    DMS 14.64
    cumene 3.41
    2-octanol 2.79
    2-hexanone 4.67
    octyl acetate 5.29
    limonene 6.04
    1,2-dimethoxyethane 11.35
    ethyl orthosilicate 11.54
    tributyl phosphate 10.51
    diacetone alcohol 30.06
    N,N-dimethylaniline 7.49
    acrylonitrile 7.47
    aniline 9.35
    1,3-propanediol 47.75
    bromobenzene 4.98
    dibromomethane 5.18
    1,1,2,2-tetrachloroethane 21.74
    2-methyl-cyclohexyl acetate 16.16
    tetrabutyl urea 13.29
    diisobutyl methanol 5.81
    2-phenylethanol 15.85
    styrene 2.02
    dioctyl adipate 9.67
    dimethyl sulfate 34.67
    ethyl butyrate 12.57
    methyl lactate 26.11
    butyl lactate 19.94
    diethyl carbonate 11.15
    propanediol butyl ether 34.28
    triethyl orthoformate 11.6
    p-tert-butyltoluene 5.18
    methyl 4-tert-butylbenzoate 24.9
    morpholine 8.34
    tert-butylamine 4.48
    n-dodecanol 1.87
    dimethoxymethane 6.63
    ethylene carbonate 34.12
    cyrene 48.9
    2-ethoxyethyl acetate 13.28
    2-ethylhexyl acetate 13.5
    1,2,4-trichlorobenzene 16.28
    4-methylpyridine 9.09
    dibutyl ether 1.91
    2,6-dimethyl-4-heptanol 5.81
    DEF 10.38
    dimethyl isosorbide 67.33
    tetrachloroethylene 26.34
    eugenol 25.92
    triacetin 19.7
    span 80 27.91
    1,4-butanediol 18.01
    1,1-dichloroethane 3.25
    2-methyl-1-pentanol 7.62
    methyl formate 22.2
    2-methyl-1-butanol 8.76
    n-decane 0.25
    butyronitrile 3.33
    3,7-dimethyl-1-octanol 6.04
    1-chlorooctane 1.21
    1-chlorotetradecane 0.57
    n-nonane 0.21
    undecane 0.21
    tert-butylcyclohexane 1.01
    cyclooctane 0.4
    cyclopentanol 21.26
    tetrahydropyran 3.31
    tert-amyl methyl ether 3.39
    2,5,8-trioxanonane 51.53
    1-hexene 1.17
    2-isopropoxyethanol 12.46
    2,2,2-trifluoroethanol 66.08
    methyl butyrate 9.48

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction