{"product_id":"chat-thom-safranal","title":"Safranal Aroma Chemical CAS# 116-26-7","description":"\u003cp\u003eSafranal (systematically named 2,6,6-trimethylcyclohexa-1,3-diene-1-carbaldehyde) is a natural organic compound belonging to the monoterpene aldehyde class. It is well known as the primary organoleptic constituent responsible for the characteristic aroma of saffron (Crocus sativus L.). Accounting for approximately 30% to 70% of the total essential volatile oil fraction of dried saffron, pure safranal is a mobile, oily liquid ranging in color from pale yellow to clear yellow or slightly green. A defining phytochemical characteristic of safranal is that it does not exist in the living, freshly harvested crocus flower. Instead, safranal is formed during the post-harvest drying process when the non-volatile glycosidic precursor picrocrocin undergoes enzymatic hydrolysis by endogenous beta-glucosidase. This reaction cleaves the beta-D-glucopyranosyl moiety, liberating D-glucose and a highly unstable, hydroxylated aglycone intermediate known as HTCC (4-hydroxy-2,6,6-trimethyl-1-cyclohexene-1-carboxaldehyde), which subsequently undergoes spontaneous thermal dehydration to yield free safranal.\u003c\/p\u003e\n\u003cp\u003eRegarding its physical and chemical properties, safranal is highly lipophilic and exhibits extremely low solubility in water (with an estimated solubility of 134.2 mg\/L at 25 °C). Conversely, it is miscible and highly soluble in organic solvents such as ethanol, diethyl ether, petroleum ether, glacial acetic acid, chloroform, and acetonitrile, as well as fixed oils. Due to the reactive conjugated diene system within its cyclohexadiene ring, safranal is highly susceptible to oxidative degradation and radical-mediated polymerization when exposed to atmospheric oxygen, ultraviolet light, and heat. Therefore, to preserve its chemical and structural integrity, it must be stored under a dry nitrogen or inert gas atmosphere at frozen temperatures (typically -20 °C) in amber glass or light-shielded containers, or stabilized with antioxidants such as tocopherol.\u003c\/p\u003e\n\u003cp\u003eIn medicine and pharmacology, safranal is valued as a precious bioactive agent due to its ability to readily cross the blood-brain barrier (BBB) owing to its small, lipophilic molecular structure. Modern scientific research has demonstrated that safranal possesses diverse pharmacological effects, including neuroprotective, anxiolytic, antidepressant, and anticonvulsant activities. It acts as a positive allosteric modulator at the benzodiazepine binding site of the \\(GABA_A\\) receptor complex, enhancing inhibitory GABAergic neurotransmission to produce calming, sedative, and anxiolytic effects. Simultaneously, it competitively inhibits the reuptake of monoamine transporters, specifically the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET), thereby elevating synaptic concentrations of these neurotransmitters to improve mood. In addition, safranal serves as a powerful antioxidant and anti-inflammatory agent by suppressing systemic inflammatory signaling cascades (such as NLRP3 and NF-\\(\\kappa\\)B), while also exhibiting cardioprotective, nephroprotective, gastroprotective, lung-protective, and in vitro cytotoxic properties against various cancer cell lines.\u003c\/p\u003e\n\u003cp\u003eBeyond its health benefits, safranal is a highly potent, premium raw material widely used in the fragrance and cosmetics industries. Its aroma is described as a warm, woody-spicy fragrance with a distinctive saffron character, featuring dry leather, straw, sweet tobacco, and herbaceous hay facets. In the food industry, safranal is recognized as a safe flavoring substance (FEMA No. 3389), with established maximum use limits in baked goods, nonalcoholic\/alcoholic beverages, jellies, and candies. In cosmetics, safranal is utilized in premium skincare formulations due to its outstanding antioxidant potential to prevent skin photoaging, maintain optimal skin hydration, and enhance photoprotection against ultraviolet radiation with a notable natural Sun Protection Factor (SPF).\u003c\/p\u003e","brand":"Scent.vn","offers":[{"title":"10g","offer_id":54638508704023,"sku":"SAFRANAL-10M","price":430000.0,"currency_code":"VND","in_stock":true},{"title":"100g","offer_id":54638508736791,"sku":"SAFRANAL-100M","price":2170000.0,"currency_code":"VND","in_stock":true},{"title":"500g","offer_id":54638508769559,"sku":"SAFRANAL-500M","price":7080000.0,"currency_code":"VND","in_stock":true},{"title":"1kg","offer_id":54638508802327,"sku":"SAFRANAL-1K","price":9700000.0,"currency_code":"VND","in_stock":true},{"title":"5kg","offer_id":54638508835095,"sku":"SAFRANAL-5K","price":44900000.0,"currency_code":"VND","in_stock":true},{"title":"10kg","offer_id":54638508867863,"sku":"SAFRANAL-10K","price":83400000.0,"currency_code":"VND","in_stock":true},{"title":"25kg","offer_id":54638508900631,"sku":"SAFRANAL-25K","price":200500000.0,"currency_code":"VND","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0744\/9886\/7479\/files\/Safranal.png?v=1786254059","url":"https:\/\/scent.vn\/en\/products\/safranal-aroma-chemical","provider":"Scent.vn","version":"1.0","type":"link"}